Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain.

@article{Zoeller2000DevelopmentalET,
  title={Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain.},
  author={R. Thomas Zoeller and Amy L S Dowling and Anna A Vas},
  journal={Endocrinology},
  year={2000},
  volume={141 1},
  pages={181-9}
}
Polychlorinated biphenyls (PCBs) are a class of industrial compounds consisting of paired phenyl rings with various degrees of chlorination. They are now ubiquitous, persistent environmental contaminants that are routinely found in samples of human and animal tissues and are known to affect brain development. The effects of PCBs on brain development may be attributable, at least in part, to their ability to reduce circulating levels of thyroid hormone. However, the developmental effects of PCB… CONTINUE READING

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Therefore , we tested whether a mixture of PCBs , Aroclor 1254 ( A1254 ) , would produce an antithyroid or thyromimetic effect on the expression of known thyroid hormone - responsive genes in the developing brain .
Therefore , we tested whether a mixture of PCBs , Aroclor 1254 ( A1254 ) , would produce an antithyroid or thyromimetic effect on the expression of known thyroid hormone - responsive genes in the developing brain .
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