Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice.

@article{Angelis2009DevelopmentalET,
  title={Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice.},
  author={Simona de Angelis and Roberta Tassinari and Francesca Maranghi and Agostino Eusepi and Antonio di Virgilio and Flavia Chiarotti and Laura Ricceri and Aldina Venerosi Pesciolini and Enzo Gilardi and Gabriele Moracci and Gemma Calamandrei and Antonella Olivieri and Alberto Mantovani},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2009},
  volume={108 2},
  pages={311-9}
}
Organophosphorus insecticides, as Chlorpyrifos (CPF), are widely used in agriculture and against household pests; these compounds receive an increasing consideration as potential endocrine disrupters. The aim of the present study was to examine the potential short- and long-term effects of CPF on thyroid and adrenal glands in CD1 mice following exposure at dose levels not inducing brain acetyl cholinesterase (AchE) inhibition, during gestational and/or postnatal vulnerable phases. Pregnant dams… CONTINUE READING