Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome

@article{Lysenko2018DevelopmentalEG,
  title={Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome},
  author={Larisa V. Lysenko and Jeesun Kim and Francisco Madamba and Anna A. Tyrtyshnaia and Alexander Kleschevnikov},
  journal={Neurobiology of Disease},
  year={2018},
  volume={115},
  pages={1-8}
}
Down syndrome (DS) is the most frequent genetic cause of developmental abnormalities leading to intellectual disability. One notable phenomenon affecting the formation of nascent neural circuits during late developmental periods is developmental switch of GABA action from depolarizing to hyperpolarizing mode. We examined properties of this switch in DS using primary cultures and acute hippocampal slices from Ts65Dn mice, a genetic model of DS. Cultures of DIV3-DIV13 Ts65Dn and control… CONTINUE READING