Developmental downregulation of GABAergic drive parallels formation of functional synapses in cultured mouse neocortical networks.

@article{Klueva2008DevelopmentalDO,
  title={Developmental downregulation of GABAergic drive parallels formation of functional synapses in cultured mouse neocortical networks.},
  author={Julia Klueva and Susanne Meis and Ana Dolabela de Lima and Thomas Voigt and Thomas Munsch},
  journal={Developmental neurobiology},
  year={2008},
  volume={68 7},
  pages={934-49}
}
Networks of cortical neurons in vitro spontaneously develop synchronous oscillatory electrical activity at around the second week in culture. However, the underlying mechanisms and in particular the role of GABAergic interneurons in initiation and synchronization of oscillatory activity in developing cortical networks remain elusive. Here, we examined the intrinsic properties and the development of GABAergic and glutamatergic input onto presumed projection neurons (PNs) and large interneurons… CONTINUE READING

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