Developmental competence of human in vitro aged oocytes as host cells for nuclear transfer.

@article{Hall2007DevelopmentalCO,
  title={Developmental competence of human in vitro aged oocytes as host cells for nuclear transfer.},
  author={Vanessa Jane Hall and Duane A. Compton and Petra Stojkovic and Maria Nesbitt and Mary Herbert and Alison P. Murdoch and Miodrag Stojkovic},
  journal={Human reproduction},
  year={2007},
  volume={22 1},
  pages={
          52-62
        }
}
BACKGROUND Improving human nuclear transfer (NT) efficiencies is paramount for the development of patient-specific stem cell lines, although the opportunities remain limited owing to difficulties in obtaining fresh mature oocytes. METHODS Therefore, the developmental competence of aged, failed-to-fertilize human oocytes as an alternate cytoplasmic source for NT was assessed and compared with use of fresh, ovulation-induced oocytes. To further characterize the developmental potential of aged… 
View on PubMed
academic.oup.com
84 Citations
Highly Influential Citations
2
Background Citations
29
Methods Citations
11
Results Citations
1

Figures and Tables from this paper

84 Citations

Citation Type

Citation Type

Developmental competence of immature and failed/abnormally fertilized human oocytes in nuclear transfer.
Developmental potential of human oocytes reconstructed by transferring somatic cell nuclei into polyspermic zygote cytoplasm.
Assessment of the developmental competence of human somatic cell nuclear transfer embryos by oocyte morphology classification.
TLDR
This study revealed that different levels of developmental competence of SCNT embryos resulting from different oocyte reprogramming potentials associated with different morphologies are revealed, and suggests that effective methods for improving oocyte quality should be studied, and that human SCNT efficiency would be increased following simple assessment of established oocyte morphology criterion.
Dynamic distribution of NuMA and microtubules in human fetal fibroblasts, developing oocytes and somatic cell nuclear transferred embryos.
TLDR
It is shown that donor cell nuclei contain NuMA, which might contribute to the maintenance of spindle morphology in SCNT embryos, and the distribution of NuMA and microtubule organization were investigated.
Development of Human Cloned Blastocysts Following Somatic Cell Nuclear Transfer with Adult Fibroblasts
TLDR
It is demonstrated, for the first time, that SCNT can produce human blastocyst‐stage embryos using nuclei obtained from differentiated adult cells and provides new information on methods that may be needed for a higher level of efficiency for human nuclear transfer.
Embryo development after successful somatic cell nuclear transfer to in vitro matured human germinal vesicle oocytes.
TLDR
This is the first report describing development of cloned human embryos using IVM oocytes and non-autologous transfer using a conventional method of SCNT.
Isolation of genes associated with developmental competency of bovine oocytes.
Developmental reprogramming after chromosome transfer into mitotic mouse zygotes
TLDR
It is reported that, unlike interphase zygote, mouse zygotes temporarily arrested in mitosis can support somatic cell reprogramming, the production of embryonic stem cell lines and the full-term development of cloned animals.
Somatic cell nuclear reprogramming of mouse oocytes endures beyond reproductive decline
TLDR
Results strongly suggest that oocyte‐induced reprogramming outcome is determined by the availability and balance of intrinsic pro‐ and anti‐reprogramming factors tightly regulated and even improved throughout aging, leading to the proposal that oocytes can still be a resource for somatic reprograming when they cease to be considered safe for sexual reproduction.
Nuclear reprogramming in zygotes.
TLDR
Assessment of the various factors that influence the reprogramming capacity of zygotes in SCNT also provide hints of the mechanistic nature of nuclear reprograming.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 56 REFERENCES
Embryogenesis and blastocyst development after somatic cell nuclear transfer in nonhuman primates: overcoming defects caused by meiotic spindle extraction.
Analysis of Gene Transcription in Bovine Nuclear Transfer Embryos Reconstructed with Granulosa Cell Nuclei1
TLDR
Comparison of transcription patterns of six developmentally important genes in single in vitro fertilized and nuclear transfer embryos reconstructed using granulosa cells for the donor nuclei shows abnormal transcription of IL6, FGF4, and FGFr2 plays an important role in implantation, early postimplantation development, or both in the mouse.
Nuclear Transfer Protocol Affects Messenger RNA Expression Patterns in Cloned Bovine Blastocysts
TLDR
An aberrant expression pattern in NT embryos was found with respect to genes thought to be involved in stress adaptation, trophoblastic function, and DNA methylation during preimplantation development.
In vivo aging of oocytes influences the behavior of nuclei transferred to enucleated rabbit oocytes
TLDR
Examining nuclear remodeling in rabbit nuclear transfer embryos formed from metaphase II (MII) oocytes aged in vivo until 19 hr postcoitum, enucleated, and fused at 22–26 hpc with 32‐cell morula blastomeres by means of electric fields revealed that transferred nuclei underwent premature chromosomes condensation (PCC) in only one‐third of NT embryos and remained in interphase in others.
Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition
TLDR
Zar1 is the first identified oocyte-specific maternal-effect gene that functions at the oocytes-to-embryo transition and, as such, offers new insights into the initiation of embryonic development and fertility control in mammals.
Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes.
Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes.
Comparison of gene transcription in cloned bovine embryos produced by different nuclear transfer techniques
TLDR
The results demonstrate the effects that different donor cell lines and different nuclear transfer procedures may have on the expression of developmentally important genes in nuclear transfer embryos.
Bovine nuclear transfer embryos: Oocyte activation prior to blastomere fusion
TLDR
Improved embryo development can be obtained from NT embryos if the aged recipient oocyte is activated prior to the time of fusion, and offspring were obtained from these pre‐activated NT embryos.
Cytogenetic analysis of human oocytes parthenogenetically activated by puromycin
TLDR
It is concluded that puromycin treatment induces retention of the second polar body in human oocytes, unlike in mouse oocytes treated in the same way.
...
1
2
3
4
5
...