Developmental competence of bovine early embryos depends on the coupled response between oxidative and endoplasmic reticulum stress.

@article{Yoon2014DevelopmentalCO,
  title={Developmental competence of bovine early embryos depends on the coupled response between oxidative and endoplasmic reticulum stress.},
  author={Seung-Bin Yoon and Seon-A Choi and Bo-Woong Sim and Ji-Su Kim and Seong-Eun Mun and Pil-Soo Jeong and Hae-Jun Yang and Youngjeon Lee and Young-Ho Park and Bong-Seok Song and Young-Hyun Kim and Kang-Jin Jeong and Jae-Won Huh and Sang-Rae Lee and Sun-Uk Kim and Kyu-Tae Chang},
  journal={Biology of reproduction},
  year={2014},
  volume={90 5},
  pages={104}
}
The stress produced by the coupling of reactive oxygen species (ROS) and endoplasmic reticulum (ER) has been explored extensively, but little is known regarding their roles in the early development of mammalian embryos. Here, we demonstrated that the early development of in vitro-produced (IVP) bovine embryos was governed by the cooperative action between ROS and ER stress. Compared with the tension produced by 5% O2, 20% O2 significantly decreased the blastocyst formation rate and cell… CONTINUE READING
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