Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice.

@article{Grossman2010DevelopmentalCO,
  title={Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice.},
  author={Aaron W Grossman and Georgina M. Aldridge and Kea Joo Lee and Michelle K. Zeman and Christine S Jun and Humza S Azam and Tatsuo Arii and Keiji Imoto and William T. Greenough and Im Joo Rhyu},
  journal={Brain research},
  year={2010},
  volume={1355},
  pages={221-7}
}
Fragile X Syndrome (FXS) is the most common form of inherited mental retardation. The neuroanatomical phenotype of adult FXS patients, as well as adult Fmr1 knockout (KO) mice, includes elevated dendritic spine density and a spine morphology profile in neocortex that resembles younger individuals. Developmental studies in mouse neocortex have revealed a dynamic phenotype that varies with age, especially during the period of synaptic pruning. Here we investigated the hippocampal dentate gyrus to… CONTINUE READING

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