Developmental changes of intracellular Ca2+ transients in beating rat hearts.

@article{Escobar2004DevelopmentalCO,
  title={Developmental changes of intracellular Ca2+ transients in beating rat hearts.},
  author={A. L. Escobar and Roberta Ribeiro-Costa and Carlos A Villalba-Galea and Mar{\'i}a Elena Zoghbi and C Guti{\'e}rrez P{\'e}rez and Rafael Mej{\'i}a-Alvarez},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 3},
  pages={H971-8}
}
Postnatal maturation of the rat heart is characterized by major changes in the mechanism of excitation-contraction (E-C) coupling. In the neonate, the t tubules and sarcoplasmic reticulum (SR) are not fully developed yet. Consequently, Ca(2+)-induced Ca(2+) release (CICR) does not play a central role in E-C coupling. In the neonate, most of the Ca(2+) that triggers contraction comes through the sarcolemma. In this work, we defined the contribution of the sarcolemmal Ca(2+) entry and the Ca(2… CONTINUE READING

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