Developmental changes of fetal rat lung Na-K-ATPase after maternal treatment with dexamethasone.

@article{Ingbar1997DevelopmentalCO,
  title={Developmental changes of fetal rat lung Na-K-ATPase after maternal treatment with dexamethasone.},
  author={David H. Ingbar and Sara Duvick and S K Savick and Dennis E Schellhase and R Detterding and James Jamieson and John M. Shannon},
  journal={The American journal of physiology},
  year={1997},
  volume={272 4 Pt 1},
  pages={L665-72}
}
Late in gestation, the prenatal fetal alveolar epithelium switches from fluid secretion to resorption of salt and water via apical sodium channels and basal Na-K-ATPase. The amounts of lung sodium pump activity protein and mRNA increase in the lung just before birth. Because maternal glucocorticoids (GC) may promote maturation of the alveolar epithelium and augment fetal surfactant apoprotein levels, we hypothesized that GC increase the fetal lung Na-K-ATPase alpha- and beta-subunit gene… CONTINUE READING