Developmental changes of calcium transients and contractility during the cultivation of rat neonatal cardiomyocytes

@article{Husse1996DevelopmentalCO,
  title={Developmental changes of calcium transients and contractility during the cultivation of rat neonatal cardiomyocytes},
  author={Britta Husse and Manfred H.P. Wussling},
  journal={Molecular and Cellular Biochemistry},
  year={1996},
  volume={163},
  pages={13-21}
}
Neonatal cardiomyocytes of the rat were investigated (a) by Confocal Laser Scanning Microscopy (CLSM) using the Ca2+-sensitive dye fluo-3/AM to measure calcium transients, and (b) by a Laser Doppler Microscope (LSC-1) to obtain data of the cell culture's contractility. Our experiments resulted in: (1) About 20% of the freshly prepared cardiomyocytes exhibited spontaneous but not rhythmically appearing calcium transients. None of these cells was found to be active mechanically. The remainder of… CONTINUE READING
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