Developmental changes of aggrecan, versican and neurocan in the retina and optic nerve.

@article{Popp2004DevelopmentalCO,
  title={Developmental changes of aggrecan, versican and neurocan in the retina and optic nerve.},
  author={Susanna Popp and Patrice Maurel and Julie S Andersen and Richard U. Margolis},
  journal={Experimental eye research},
  year={2004},
  volume={79 3},
  pages={
          351-6
        }
}
We have used a monoclonal antibody to neurocan and specific polyclonal antibodies to the non-homologous glycosaminoglycan attachment regions of aggrecan and mRNA splice variants of versican to compare the localization and developmental changes of these structurally related hyaluronan-binding chondroitin sulfate proteoglycans in the rat retina and optic nerve. Staining for aggrecan and versican was first seen at embryonic day 16 in the optic nerve and retina, whereas neurocan was not detected in… CONTINUE READING
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