Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver.

@article{Chow1999DevelopmentalCI,
  title={Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver.},
  author={Toshio Chow and Susumu Imaoka and Toyoko Hiroi and Yoshihiko Funae},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 2},
  pages={188-92}
}
Developmental changes in bufuralol 1'-hydroxylation activity, which is known as a typical activity of cytochrome P-450 (CYP)2D isoforms, in the liver of rats were investigated. The catalytic activities of hepatic microsomes increased with development especially from 3 to 7 weeks. Eadie-Hofstee plots of bufuralol 1'-hydroxylation were obtained for monophasic kinetics (Km: 0.037 microM) at 1 week and for biphasic kinetics (Km: 0.051 and 6.4 microM) at 7 weeks of age. Quinine completely inhibited… CONTINUE READING

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