Developmental changes in structural and functional properties of hippocampal AMPARs parallels the emergence of deliberative spatial navigation in juvenile rats.

@article{Blair2013DevelopmentalCI,
  title={Developmental changes in structural and functional properties of hippocampal AMPARs parallels the emergence of deliberative spatial navigation in juvenile rats.},
  author={Margaret G Blair and Nhu N-Q Nguyen and Sarah H. Albani and Matthew M L'Etoile and Marina M. Andrawis and Leanna M. Owen and Rodrigo Franco Oliveira and Matthew Wong Johnson and Dianna L Purvis and Erin Morgan Sanders and Emily T. Stoneham and Huaying Xu and Theodore C Dumas},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 30},
  pages={
          12218-28
        }
}
The neural mechanisms that support the late postnatal development of spatial navigation are currently unknown. We investigated this in rats and found that an increase in the duration of AMPAR-mediated synaptic responses in the hippocampus was related to the emergence of spatial navigation. More specifically, spontaneous alternation rate, a behavioral indicator of hippocampal integrity, increased at the end of the third postnatal week in association with increases in AMPAR response duration at… CONTINUE READING
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