Developmental changes in ovine corticotrophs in vitro.

@article{Perez1997DevelopmentalCI,
  title={Developmental changes in ovine corticotrophs in vitro.},
  author={F M Perez and Jessica Schwartz and James C. Rose},
  journal={Endocrinology},
  year={1997},
  volume={138 3},
  pages={
          916-21
        }
}
We recently reported that fetal sheep corticotrophs (ACTH-producing cells) at 108 +/- 5 d (days) of gestation are relatively more responsive to CRH than to AVP, whereas those at 139 +/- 0 d (term = 145 d) and in the adult are more responsive to AVP. To further characterize these developmental changes, we used immunocytochemical, RIA, and cell immunoblotting techniques to examine populations of corticotrophs and individual cells. Immunocytochemical studies revealed that corticotroph frequency… CONTINUE READING

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