Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung.

@article{Shaul2002DevelopmentalCI,
  title={Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung.},
  author={Philip W. Shaul and Sam Afshar and Linda L. Gibson and Todd S. Sherman and Jay D Kerecman and Peter H Grubb and Bradley A. Yoder and Donald C. McCurnin},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={283 6},
  pages={L1192-9}
}
Nitric oxide (NO), produced by NO synthase (NOS), plays a critical role in multiple processes in the lung during the perinatal period. To better understand the regulation of pulmonary NO production in the developing primate, we determined the cell specificity and developmental changes in NOS isoform expression and action in the lungs of third-trimester fetal baboons. Immunohistochemistry in lungs obtained at 175 days (d) of gestation (term = 185 d) revealed that all three NOS isoforms, neuronal… CONTINUE READING