Developmental changes in intracellular pH regulation in medullary neurons of the rat.

  title={Developmental changes in intracellular pH regulation in medullary neurons of the rat.},
  author={Stephen M Nottingham and James C Leiter and Page Wages and Shelly Buhay and Joseph S. Erlichman},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={281 6},
We examined intracellular pH (pH(i)) regulation in the retrotrapezoid nucleus (RTN), a CO(2)-sensitive site, and the hypoglossal nucleus, a nonchemosensitive site, during development (postnatal days 2-18) in rats. Respiratory acidosis [10% CO(2), extracellular pH (pH(o)) 7.18] caused acidification without pH(i) recovery in the RTN at all ages. In the hypoglossal nucleus, pH(i) recovered in young animals, but as animal age increased, the slope of pH(i) recovery diminished. In animals older than… CONTINUE READING
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Intracellular pH responses to hypercapnia in neurons from chemosensitive areas R1950 DEVELOPMENTAL CHANGES IN MEDULLARY PH REGULATION AJP-Regulatory Integrative Comp Physiol

  • NA Ritucci, JB Dean, RW. Putnam
  • Am J Physiol Regulatory Integrative Comp Physiol…
  • 2001
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