Developmental changes in hypothalamic Kiss1 expression during activation of the pulsatile release of luteinising hormone in maturing ewe lambs.

@article{Redmond2011DevelopmentalCI,
  title={Developmental changes in hypothalamic Kiss1 expression during activation of the pulsatile release of luteinising hormone in maturing ewe lambs.},
  author={J S Redmond and G M Baez-Sandoval and K M Spell and Thomas E Spencer and Clay A Lents and Gary L. Williams and Marcel Amstalden},
  journal={Journal of neuroendocrinology},
  year={2011},
  volume={23 9},
  pages={815-22}
}
Onset of puberty is characterised by a marked increase in the frequency of release of gonadotrophin-releasing hormone (GnRH) and luteinising hormone (LH). The Kiss1 gene plays a critical role in pubertal development, and its product, kisspeptin, stimulates GnRH and LH release. In the present study, we tested the hypothesis that Kiss1 gene expression in the preoptic area (POA) and hypothalamus increases during maturation of the reproductive neuroendocrine axis in association with increased LH… CONTINUE READING

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The Authors

J. S. Redmond
Journal of Neuroendocrinology a 2011 Blackwell Publishing Ltd, Journal of Neuroendocrinology, • 2011

Mutations of the KISS1 gene in disorders of puberty

BB Mendonca, UB Kaiser, AC. Latronico
J Clin Endocrinol Metab • 2010

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