Developmental changes in human liver CYP2D6 expression.

  title={Developmental changes in human liver CYP2D6 expression.},
  author={Jeffrey C. Stevens and Sandra A Marsh and Matthew J Zaya and Karen J Regina and Karthika Divakaran and Min Thong Le and Ronald N Hines},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={36 8},
Within the human cytochrome P450 family, specific forms show developmental expression patterns that can affect drug clearance, efficacy, and safety. The objective of this study was to use dextromethorphan O-demethylase activity and quantitative Western blotting to identify CYP2D6 developmental expression patterns in a large (n = 222) and developmentally diverse set of pediatric liver samples. Immunodetectable levels of CYP2D6 protein determined for selected samples across all age categories… CONTINUE READING


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