Developmental changes in hepatic microsomal interactions between UDP-glucuronyltransferase and phospholipid in the rat fetus.

Abstract

The interaction of hepatic microsomal UDP-glucuronyltransferase (UDPGT) and phospholipid was studied using rat fetuses from the 16th to 21st day of gestation. UDPGT activity for phenol and p-phenylbenzoic acid, and phospholipid content and fluidity increased with day of gestation. Digestion of microsomes with phospholipase A2 removed a similar ratio of… (More)

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