Developmental changes in central O2 chemoreflex in Rana catesbeiana: the role of noradrenergic modulation.

@article{Fournier2007DevelopmentalCI,
  title={Developmental changes in central O2 chemoreflex in Rana catesbeiana: the role of noradrenergic modulation.},
  author={St{\'e}phanie Fournier and Mathieu Allard and St{\'e}phanie Roussin and Richard Kinkead},
  journal={The Journal of experimental biology},
  year={2007},
  volume={210 Pt 17},
  pages={3015-26}
}
The in vitro brainstem preparation from Rana catesbeiana shows a functional central O(2) chemoreflex. Acute brainstem exposure to hypoxic superfusate elicits lung burst frequency responses that change over the course of development. Based on studies suggesting that brainstem noradrenergic neurons are involved in this reflex, we tested the following two hypotheses in vitro: (1) activation of adrenoceptors is necessary for the expression of the fictive lung ventilation response to hypoxia, and (2… CONTINUE READING

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