Developmental changes in central O2 chemoreflex in Rana catesbeiana: the role of noradrenergic modulation

@article{Fournier2007DevelopmentalCI,
  title={Developmental changes in central O2 chemoreflex in Rana catesbeiana: the role of noradrenergic modulation},
  author={St{\'e}phanie Fournier and Mathieu Allard and Stéphanie Roussin and Richard Kinkead},
  journal={Journal of Experimental Biology},
  year={2007},
  volume={210},
  pages={3015 - 3026},
  url={https://api.semanticscholar.org/CorpusID:6669009}
}
It is concluded that NA modulation contributes to the central O2 chemoreflex in bullfrog, which acts via GABA/glycine pathways, and changes in fast, Cl–-dependent neurotransmission (GABA/ Glycine) contribute to developmental changes in noradrenergic modulation.
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31 Citations

Role of pontine neurons in central O2 chemoreflex during development in bullfrogs (Lithobates catesbeiana)

Orexin-A inhibits fictive air breathing responses to respiratory stimuli in the bullfrog tadpole (Lithobates catesbeianus).

It is concluded that ORX neurons provide inhibitory modulation of the CO2 and O2 chemoreflexes in pre-metamorphic tadpoles.

Persistent augmentation of fictive air breathing by hypoxia: An in vitro study of the role of GABAB signaling in pre-metamorphic tadpoles.

Role of glutamate and substance P in the amphibian respiratory network during development

Control of Breathing in In Vitro Brain Stem Preparation from Goldfish (Carassius auratus; Linnaeus)

It is concluded that respiratory activity produced by the goldfish brain stem is not responsive to the moderate CO2 levels used in this study; it may contain O2 chemoreceptors, but the relatively small response could also reflect nonspecific effects of hypoxia on the central nervous system.

Central CO2 chemosensitivity in tadpoles: impairment and the role of serotonin

The electrophysiological and immunofluorescence data suggest the effects of ethanol or nicotine exposure, which impair the hypercapnic response, include a failure of serotonergic signaling and that this failure is not simply the reflection of a global reduction in serotonin levels.

Noradrenergic tuning, not simple rate effects, produces temperature‐sensitivity of the respiratory network in bullfrogs

It is demonstrated that the frequency of respiratory‐related nerve activity is stable across high temperatures, but not lower temperatures, which implies that norepinephrine tuning through different receptors, rather than simple Q10 effects, plays a major role in generating the breathing frequency across temperatures to match metabolic demands and acid‐base regulation requirements at those temperatures.

Noradrenergic modulation determines respiratory network activity during temperature changes in the in vitro brainstem of bullfrogs

Isolated adult turtle brainstems exhibit central hypoxic chemosensitivity.

Central Hypoxia Elicits Long-Term Expression of the Lung Motor Pattern in Pre-metamorphic Lithobates Catesbeianus.

Preliminary results suggest that central hypoxia elicits long-term increases in lung burst frequency in a severity- and stage-dependent manner.

42 References

Development of the respiratory response to hypoxia in the isolated brainstem of the bullfrog Rana catesbeiana

Results indicate that pre-metamorphic tadpoles are capable of maintaining respiratory activity for 3 h or more during severe hypoxia and rely to a great extent upon anaerobic metabolism to maintain respiratory motor output.

Noradrenergic modulation of respiratory motor output during tadpole development: role of α-adrenoceptors

It is concluded that modulation of both buccal and lung-related motor outputs change during development, owing to the different adrenoceptor type involved.

Regulation of the respiratory central pattern generator by chloride-dependent inhibition during development in the bullfrog (Rana catesbeiana).

It is hypothesized that maturation of the bullfrog respiratory CPG reflects developmental changes in glycinergic and/or GABAergic synaptic inhibitory mechanisms and that lung ventilation in the tadpole brainstem may be driven by a pacemaker-like mechanism since Cl(-)-free aCSF failed to abolish lung ventilation.

Role of chloride‐mediated inhibition in respiratory rhythmogenesis in an in vitro brainstem of tadpole, Rana catesbeiana.

It is concluded that different neural systems generate rhythmic activity for lung and gill ventilation, and chloride channel‐dependent inhibitory mechanisms mediated by GABA(A) and/or glycine receptors may be essential for generation of neural bursts associated with gills ventilation.

Ontogeny of central chemoreception during fictive gill and lung ventilation in an in vitro brainstem preparation of Rana catesbeiana

The ontological development of central respiratory chemoreceptors driving respiratory output in the larval amphibian is described, demonstrating transfer in central chemoreceptive influence from gill to lung regulation during metamorphic stages and providing novel evidence for the stimulatory influence of central che moreceptors on fictive gill ventilation in response to CO2.

Developmental changes in the modulation of respiratory rhythm generation by extracellular K+ in the isolated bullfrog brainstem.

Lung burst activity in amphibians may shift from a "voltage-dependent" state to a " voltage-independent" state during development, consistent with the hypothesis that the fundamental mechanisms generating respiratory rhythm in the amphibian brainstem change during development.

Vagal input enhances responsiveness of respiratory discharge to central changes in pH/CO2 in bullfrogs.

It appears that episodic breathing is an intrinsic property of the central nervous system in bullfrogs and there is a strong interaction between vagal feedback and central chemodetection in controlling the temporal relationships that characterize this episodi breathing pattern.

Noradrenergic modulation of the medullary respiratory rhythm generator in the newborn rat: an in vitro study.

Stimulation, lesion and NA microejection experiments suggested that the main site of NA action is located in the rostral ventrolateral medulla, where electrical stimulations triggered inspiration prematurely, lesions suppressed the NA‐induced decrease in respiratory frequency, and localized application of NA led to an immediate decrease in the respiratory frequency.

Serotonergic modulation of respiratory motor output during tadpole development.

It is concluded that serotonergic modulation of respiratory motor output changes during tadpole development and 2) is distinct for gill and lung ventilation, which is mediated by 5-HT(1A)-receptor activation in an age-dependent fashion.

Neural organization of the ventilatory activity in the frog, Rana catesbeiana. I.

It is concluded that oropharyngeal and pulmonary ventilation of the frog are produced by one or, possibly, two intrinsically active generators.