Developmental changes in NMDA and non-NMDA receptor-mediated synaptic potentials in rat neocortex.

@article{Burgard1993DevelopmentalCI,
  title={Developmental changes in NMDA and non-NMDA receptor-mediated synaptic potentials in rat neocortex.},
  author={Edward C Burgard and John J Hablitz},
  journal={Journal of neurophysiology},
  year={1993},
  volume={69 1},
  pages={230-40}
}
1. In vitro slices of frontal neocortex were prepared from rat pups 3-14 days of age. Whole-cell patch-clamp recordings were obtained from layer II-III cortical neurons, and measurements of passive membrane properties were made. The development of evoked synaptic excitation and inhibition was also examined with the use of current- and voltage-clamp techniques. 2. Pharmacological separation of excitatory synaptic activity into both N-methyl-D-aspartate (NMDA) and non-NMDA receptor-mediated… CONTINUE READING
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