Developmental changes and injury induced disruption of the radial organization of the cortex in the immature rat brain revealed by in vivo diffusion tensor MRI.

@article{Sizonenko2007DevelopmentalCA,
  title={Developmental changes and injury induced disruption of the radial organization of the cortex in the immature rat brain revealed by in vivo diffusion tensor MRI.},
  author={St{\'e}phane V. Sizonenko and Emily Jane Camm and Joel R. Garbow and Stephan E. Maier and Terrie E. Inder and Chris E. Williams and Jeffrey J. Neil and Petra S. Huppi},
  journal={Cerebral cortex},
  year={2007},
  volume={17 11},
  pages={2609-17}
}
During brain development, morphological changes modify the cortex from its immature radial organization to its mature laminar appearance. Applying in vivo diffusion tensor imaging (DTI), the microstructural organization of the cortex in the immature rat was analyzed and correlated to neurohistopathology. Significant differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were detected between the external (I-III) and deep (IV-VI) cortical layers in postnatal day 3 (P3… CONTINUE READING
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