Developmental change of GABAA receptor-mediated current in rat hippocampus

  title={Developmental change of GABAA receptor-mediated current in rat hippocampus},
  author={Megumi Taketo and Tohru Yoshioka},

Development of GABA(A) receptor-mediated inhibitory postsynaptic currents in hippocampus.

The rate, amplitude, and kinetics of GABA(A,fast) mIPSCs showed significant changes between P10 and P30, suggesting counterbalancing changes in action potential-dependent inhibitory postsynaptic currents in IPSCs, consistent with the hypothesis that developmental changes in GABA (A,slow) IPSCs are due to changes in presynaptic excitability.

Transition from GABAergic to glycinergic synaptic transmission in newly formed spinal networks.

The role of glycinergic and GABAergic systems in mediating spontaneous synaptic transmission in newly formed neural networks was examined in motoneurons in the developing rat spinal cord, indicating that GABAergic synaptic sites were functionally dominant at early stages of neural network formation.

Sensitivity of synaptic GABAA receptors to allosteric modulators in hippocampal oriens‐alveus interneurons

This pharmacological profile suggests that GABAA receptors at spontaneously active inhibitory synapses onto vertical and horizontal interneurons are heterogeneous and formed by co‐assembly of different combinations of subunits (α1–5β1–3γ1–4–3).

Differential pharmacological properties of GABAA receptors in axon terminals and soma of dentate gyrus granule cells

The results suggest that the pharmacological properties of GABAA receptors differ considerably between presynaptic (axon terminals) and somatic regions in the same granule cell and thatPresynaptic GAB AA receptors should be considered as one of the important pharmacological targets of many drugs affecting GABaa receptors.

Differential Plasticity of the GABAergic and Glycinergic Synaptic Transmission to Rat Lumbar Motoneurons after Spinal Cord Injury

It is concluded that the plasticity of GlyR is independent of supraspinal influences whereas that of GABAAR is markedly influenced by descending pathways, in particular serotoninergic projections.

Development and Modulation of GABAA Receptor-mediated Neurotransmission in the CA1 Region of Prenatally Protein Malnourished Rats

Recordings of CA1 pyramidal cells demonstrate that the previously observed alterations in the serotonergic and GABAergic systems that result from prenatal protein malnutrition do not have significant functional consequences at a single cell level in the CA1 region of the rat hippocampus as measured in vitro.

Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus




Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acidA receptor pharmacological properties.

It is suggested that dentate granule cells in young and adult animals express pharmacologically distinct GABAA receptors and that the postnatal development of these receptors is prolonged, lasting at least 45 days.

Developmental study of benzodiazepine effects on monosynaptic GABAA-mediated IPSPs of rat hippocampal neurons.

Results indicate that the regulation by benzodiazepine of GABAA-mediated IPSPs varies with the developmental stage.

Slow Kinetics of Miniature IPSCs during Early Postnatal Development in Granule Cells of the Dentate Gyrus

The results reveal for the first time that until the end of the second postnatal week the synaptic GABAA receptor-mediated currents in dentate granule cells display slower rise and decay kinetics but similar amplitudes compared with adult, resulting in a net decrease in synaptic charge transfer during development.

Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neurons.

Results show that neocortical pyramidal cells have a population of GABAA receptors sensitive to both zinc and zolpidem, which enhanced mIPSCs in a concentration-dependent manner.

Giant synaptic potentials in immature rat CA3 hippocampal neurones.

In neurones in which evoked GDPs were blocked by bicuculline, a NMDA‐mediated component was revealed by increasing the strength or the frequency of stimulation, and during the second week of postnatal life, superfusion with bicuciulline induced, as in adult slices, interictal discharges.

The Synaptic Basis of GABAA,slow

Evidence is presented here that both evoked responses are synaptic in origin, because two classes of minimally evoked, spontaneous and miniature IPSCs exist that correspond to GABAA,fast and GabAA,slow.

GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms

  • T. BeharY‐X. Li J. Barker
  • Biology, Chemistry
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
GA-stimulated increases in intracellular Ca2+ may mediate both chemotactic and chemokinetic responses in embryonic cortical cells.

Dependence of the GABAA receptor gating kinetics on the alpha‐subunit isoform: implications for structure‐function relations and synaptic transmission.

Results indicate that substitution of the alpha 3 subunit variant in an alpha 1 beta 2 gamma 2S receptor alters transition rates involved in ligand binding that underlie changes in apparent activating site affinity and macroscopic current gating.