Developmental change of GABAA receptor-mediated current in rat hippocampus

@article{Taketo2000DevelopmentalCO,
  title={Developmental change of GABAA receptor-mediated current in rat hippocampus},
  author={M. Taketo and T. Yoshioka},
  journal={Neuroscience},
  year={2000},
  volume={96},
  pages={507-514}
}
Developmental change of GABA(A)ergic inhibitory postsynaptic current in rat hippocampal CA3 region was examined using patch-clamp recording method. Spontaneous and evoked inhibitory postsynaptic currents were recorded from acute hippocampal slices of neonates (postnatal days 2-4) and adults (days 18-38). Decay kinetics of the spontaneous inhibitory postsynaptic current was slower in neonates than in adults. Application of 500 nM zolpidem increased decay time-constants of the inhibitory… Expand
Development of GABA(A) receptor-mediated inhibitory postsynaptic currents in hippocampus.
TLDR
The rate, amplitude, and kinetics of GABA(A,fast) mIPSCs showed significant changes between P10 and P30, suggesting counterbalancing changes in action potential-dependent inhibitory postsynaptic currents in IPSCs, consistent with the hypothesis that developmental changes in GABA (A,slow) IPSCs are due to changes in presynaptic excitability. Expand
Transition from GABAergic to glycinergic synaptic transmission in newly formed spinal networks.
TLDR
The role of glycinergic and GABAergic systems in mediating spontaneous synaptic transmission in newly formed neural networks was examined in motoneurons in the developing rat spinal cord, indicating that GABAergic synaptic sites were functionally dominant at early stages of neural network formation. Expand
Short-term inhibition of GABAergic IPSCs induced by association of pre- and postsynaptic activation in the neonatal hippocampus
TLDR
Results show that weak postsynapticactivation, when combined with presynaptic activation, leads to an inhibition of GABAergic synapses in the neonatal hippocampus, mediated by a mechanism involving mGluRs, mAChRs, and CB1 receptors, and potentiated by NMDA receptor activation. Expand
Developmental change of GABAergic postsynaptic current in rat periaqueductal gray
TLDR
It is demonstrated that a decrease in the amplitude of GABAergic mIPSC during development may result from a decreases in the GABA contents of synaptic vesicles and from changes in the kinetics of postsynaptic GABA-activated Cl- channels. Expand
Inhibition of different GABA transporter systems is required to attenuate epileptiform activity in the CA3 region of the immature rat hippocampus
TLDR
It is concluded that both Gat-1 and GAT-2/3 act synergistically to regulate the excitability in the immature hippocampus, and that only the combined inhibition of GAT 1-3 is sufficient to promote a considerable anticonvulsive effect. Expand
Sensitivity of synaptic GABAA receptors to allosteric modulators in hippocampal oriens‐alveus interneurons
TLDR
This pharmacological profile suggests that GABAA receptors at spontaneously active inhibitory synapses onto vertical and horizontal interneurons are heterogeneous and formed by co‐assembly of different combinations of subunits (α1–5β1–3γ1–4–3). Expand
Differential pharmacological properties of GABAA receptors in axon terminals and soma of dentate gyrus granule cells
TLDR
The results suggest that the pharmacological properties of GABAA receptors differ considerably between presynaptic (axon terminals) and somatic regions in the same granule cell and thatPresynaptic GAB AA receptors should be considered as one of the important pharmacological targets of many drugs affecting GABaa receptors. Expand
Differential Plasticity of the GABAergic and Glycinergic Synaptic Transmission to Rat Lumbar Motoneurons after Spinal Cord Injury
TLDR
It is concluded that the plasticity of GlyR is independent of supraspinal influences whereas that of GABAAR is markedly influenced by descending pathways, in particular serotoninergic projections. Expand
Calcium-independent inhibition of GABAA current by caffeine in hippocampal slices
TLDR
It is suggested that intracellular Ca2+ mobilization through ryanodine-sensitive store stimulation does not significantly affect GABAergic IPSCs, and most of the inhibitory effect of caffeine is independent of [Ca2+]i elevation under the present experimental conditions. Expand
Development and Modulation of GABAA Receptor-mediated Neurotransmission in the CA1 Region of Prenatally Protein Malnourished Rats
TLDR
Recordings of CA1 pyramidal cells demonstrate that the previously observed alterations in the serotonergic and GABAergic systems that result from prenatal protein malnutrition do not have significant functional consequences at a single cell level in the CA1 region of the rat hippocampus as measured in vitro. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 16 REFERENCES
Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acidA receptor pharmacological properties.
TLDR
It is suggested that dentate granule cells in young and adult animals express pharmacologically distinct GABAA receptors and that the postnatal development of these receptors is prolonged, lasting at least 45 days. Expand
gamma-Aminobutyric acid (GABA): a fast excitatory transmitter which may regulate the development of hippocampal neurones in early postnatal life.
TLDR
It is suggested that during the first postnatal week of life, when excitatory inputs are still poorly developed, GABAA receptors provide theexcitatory drive necessary for pyramidal cell outgrowth. Expand
Involvement of GABAA receptors in the outgrowth of cultured hippocampal neurons
TLDR
This study suggests that GABA, acting on GABAA subtype of receptors, is able to affect the development of the hippocampus. Expand
Developmental study of benzodiazepine effects on monosynaptic GABAA-mediated IPSPs of rat hippocampal neurons.
TLDR
Results indicate that the regulation by benzodiazepine of GABAA-mediated IPSPs varies with the developmental stage. Expand
Slow Kinetics of Miniature IPSCs during Early Postnatal Development in Granule Cells of the Dentate Gyrus
TLDR
The results reveal for the first time that until the end of the second postnatal week the synaptic GABAA receptor-mediated currents in dentate granule cells display slower rise and decay kinetics but similar amplitudes compared with adult, resulting in a net decrease in synaptic charge transfer during development. Expand
Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neurons.
TLDR
Results show that neocortical pyramidal cells have a population of GABAA receptors sensitive to both zinc and zolpidem, which enhanced mIPSCs in a concentration-dependent manner. Expand
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
TLDR
In neurones in which evoked GDPs were blocked by bicuculline, a NMDA‐mediated component was revealed by increasing the strength or the frequency of stimulation, and during the second week of postnatal life, superfusion with bicuciulline induced, as in adult slices, interictal discharges. Expand
The Synaptic Basis of GABAA,slow
TLDR
Evidence is presented here that both evoked responses are synaptic in origin, because two classes of minimally evoked, spontaneous and miniature IPSCs exist that correspond to GABAA,fast and GabAA,slow. Expand
GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms
  • T. Behar, Y. Li, +4 authors J. Barker
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
TLDR
GA-stimulated increases in intracellular Ca2+ may mediate both chemotactic and chemokinetic responses in embryonic cortical cells. Expand
Dependence of the GABAA receptor gating kinetics on the alpha‐subunit isoform: implications for structure‐function relations and synaptic transmission.
TLDR
Results indicate that substitution of the alpha 3 subunit variant in an alpha 1 beta 2 gamma 2S receptor alters transition rates involved in ligand binding that underlie changes in apparent activating site affinity and macroscopic current gating. Expand
...
1
2
...