Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration

@article{Singh2008DevelopmentalAP,
  title={Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration},
  author={Karun K Singh and Katya J. Park and Elizabeth J. Hong and Bianca Kramer and Michael E. Greenberg and David R Kaplan and F. D. Miller},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={649-658}
}
The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor (BDNF) in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause their degeneration and, ultimately, axon pruning. Specifically, we found that pruning of rat and mouse sympathetic axons that project to the… CONTINUE READING
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