Developmental aspects of the pilocarpine model of epilepsy.

@article{Priel1996DevelopmentalAO,
  title={Developmental aspects of the pilocarpine model of epilepsy.},
  author={Margareth Rose Priel and Neusa Fernandes dos Santos and Esper Abr{\~a}o Cavalheiro},
  journal={Epilepsy research},
  year={1996},
  volume={26 1},
  pages={115-21}
}
Prolonged seizures in young children may precede the later development of focal or generalized seizures. To study the age-related susceptibility to the development of chronic epilepsy we used the pilocarpine model of epilepsy (PME). This model is well characterized in adult rats, and presents three distinct periods: (a) an acute period of status epilepticus (SE), (b) a silent period of a progressive normalization of EEG and behavior, (c) a chronic period of spontaneous recurrent seizures… CONTINUE READING

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