Developmental aspects of environmental neurotoxicology: Lessons from lead and polychlorinated biphenyls

  title={Developmental aspects of environmental neurotoxicology: Lessons from lead and polychlorinated biphenyls},
  author={Gerhard Winneke},
  journal={Journal of the Neurological Sciences},
  • G. Winneke
  • Published 15 September 2011
  • Psychology
  • Journal of the Neurological Sciences

The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences

Recent data demonstrates that PCB 11 modulates neuronal morphogenesis via mechanisms that are convergent with and divergent from those implicated in the developmental neurotoxicity of legacy NDL PCBs.

The association of environmental toxicants and autism spectrum disorders in children.

Trace elements as paradigms of developmental neurotoxicants: Lead, methylmercury and arsenic.

  • P. GrandjeanKatherine T. Herz
  • Psychology
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2015

Short title : zebrafish DNT for human risk assessment

Some of the advantages of using zebrafish in developmental neurotoxicity testing are discussed, focusing on central nervous system development, neurobehavior, toxicokinetics, and toxicodynamics in this species.

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Evidence from human and animal studies is presented for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity.

Approaches to Understanding Mechanisms between Environmental Chemical Exposure and Brain Development

This paper aims at contributing to the field of neuroscience by clarifying key processes, noting unresolved issues in previous experimental works and illuminating on mechanistic approaches to be tested with proper and robust research design of the 21st century.

Persistent organic pollutants at the synapse: Shared phenotypes and converging mechanisms of developmental neurotoxicity

Identifying converging pathological mechanisms elicited by POP exposure at the synapse can define future research directions that will advance the understanding of these chemicals on synapse structure and function, and highlight research gaps that merit consideration.



Developmental neurotoxicity of industrial chemicals

Effects of PCB exposure on neuropsychological function in children.

It is revealed that the PCB residues in environmental media and human tissues may not closely resemble any of the commercial PCB mixtures, depending on source of exposure, bioaccumulation through the food chain, and weathering of PCBs in the environment.

Intellectual impairment in children exposed to polychlorinated biphenyls in utero.

Prenatal exposure to polychlorinated biphenyls was associated with lower full-scale and verbal IQ scores and the strongest effects related to memory and attention, suggesting that the developing fetal brain is particularly sensitive to these compounds.

Blood lead levels and specific attention effects in young children.

Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis

Environmental lead exposure in children who have maximal blood lead levels < 7.5 μg/dL is associated with intellectual deficits, and an inverse relationship between blood lead concentration and IQ score is found.

Exposures to Environmental Toxicants and Attention Deficit Hyperactivity Disorder in U.S. Children

Exposure to prenatal tobacco and environmental lead are risk factors for ADHD in U.S. children, and if causally linked, these data suggest that prenatal tobacco exposure accounts for 270,000 excess cases of ADHD, and lead Exposure accounts for 290,000 extra cases of ADD.

Effects of prenatal PCB and dioxin background exposure on cognitive and motor abilities in Dutch children at school age.

Negative effects of prenatal PCB and dioxin exposure on cognitive and motor abilities were seen when parental and home characteristics were less optimal, and these effects were not measurable in children raised in more optimal environments.