Developmental and seizure-related regional differences in immediate early gene expression and GABAergic abnormalities in the brain of EL mice.

@article{Murashima1996DevelopmentalAS,
  title={Developmental and seizure-related regional differences in immediate early gene expression and GABAergic abnormalities in the brain of EL mice.},
  author={Yoshiya L. Murashima and K Kassamo and Jiro Suzuki},
  journal={Epilepsy research},
  year={1996},
  volume={26 1},
  pages={3-14}
}
To examine the hypothesized role of the immediate early gene (IEG) response in synaptic plasticity and in epileptogenesis, we studied the spatial specificity of the expression of IEG in EL mice, a well known mutant model of epilepsy. Also to examine the 'GABA hypothesis' in epilepsy, GABA concentration and GAD activity was determined in micro brain regions… CONTINUE READING