Developmental and reproductive performance in circadian mutant mice.

@article{Dolatshad2006DevelopmentalAR,
  title={Developmental and reproductive performance in circadian mutant mice.},
  author={Hamid Dolatshad and Elizabeth A. Campbell and Laura O’Hara and Elizabeth S. Maywood and Michael H. Hastings and M. H. Johnson},
  journal={Human reproduction},
  year={2006},
  volume={21 1},
  pages={
          68-79
        }
}
BACKGROUND Genes underlying circadian rhythm generation are expressed in many tissues. [] Key MethodRESULTS Uteri from Clock(Delta19) mice show no circadian rhythm and Vipr2-/- mice show a phase-advanced rhythm compared to WT uteri. In neither mutant line were homozygous or heterozygous fetuses lethal. Sexually mature adults of both mutant lines showed mildly reduced male in vivo (but not in vitro) fertility and irregular estrous cycles exacerbated by continuous darkness. However, pregnancy rates and…
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It is demonstrated that Clock mutation disrupts daily maternal behavior and the growth and survival rate of pups, especially with the breeding of more than 10 pups.
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Fetal growth within a genetically disrupted circadian environment during gestation has no effect on pregnancy success, and only marginal impacts upon the long-term metabolic health of offspring, and the hypothesis that circadian rhythm disruption during pregnancy programs poor metabolic homeostasis in offspring is not supported.
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The role of circadian rhythmicity in the control of reproductive function in animals and humans is discussed and there is emerging evidence that the primary clock genes, Clock and Bmal1 (Brain and Muscle ARNT-like protein 1, also known as Mop3), strongly influence reproductive competency.
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TLDR
Repeated shifting of the LD cycle, which disrupts endogenous circadian timekeeping, dramatically reduces pregnancy success in mice, suggesting that the magnitude or duration of circadian misalignment may be related to the severity of the adverse impact on pregnancy.
Disrupted Reproduction, Estrous Cycle, and Circadian Rhythms in Female Mice Deficient in Vasoactive Intestinal Peptide
TLDR
The simplest explanation of the data is that the loss of VIP results in a weakened SCN oscillator, which reduces the synchronization of the female circadian system, which clarify one of the mechanisms by which disruption of the circadian system reduces female reproductive success.
Circadian rhythms and fertility
Circadian clock genes in reproductive tissues and the developing conceptus.
The circadian (near 24-h) clock is involved in the temporal organisation of physiological and biochemical activities of many organisms, including humans. The clock functions through the rhythmic…
The Noncircadian Function of the Circadian Clock Gene in the Regulation of Male Fertility
TLDR
Results provide the first evidence that Clock gene expression in round spermatids is essential for maintaining male reproductivity and suggest that acrosin may be a novel regulatory target of the Clock gene that would regulate the fertilization and early embryonic development to blastula.
Differential Expression of the Circadian Clock in Maternal and Embryonic Tissues of Mice
TLDR
Results show that embryonic tissues express key circadian genes and have the capacity to express active circadian regulatory cycles, suggesting the importance of a synchronizing signal for the expression of circadian cycles in developing tissues.
The disruption of circadian clockwork in differentiating cells from rat reproductive tissues as identified by in vitro real-time monitoring system.
TLDR
The oscillation of Per2 gene expression is characterized in several types of ovarian, uterine, and testicular cells, and it is strongly suggested that circadian clockwork is affected during cellular differentiation.
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