Developmental and epigenetic anomalies in cloned cattle.

  title={Developmental and epigenetic anomalies in cloned cattle.},
  author={Lawrence Charles Smith and Jo{\~a}o Suzuki and Alan K Goff and France Filion and Jacinthe Therrien and Bruce Douglas Murphy and Hamid-Reza Kohan-Ghadr and R{\'e}jean Lefebvre and A. C. Brisville and S Buczinski and Gilles Fecteau and Felipe Perecin and Fl{\'a}vio Vieira Meirelles},
  journal={Reproduction in domestic animals = Zuchthygiene},
  volume={47 Suppl 4},
Many of the developmental anomalies observed in cloned animals are related to foetal and placental overgrowth, a phenomenon known as the 'large offspring syndrome' (LOS) in ruminants. It has been hypothesized that the epigenetic control of imprinted genes, that is, genes that are expressed in a parental-specific manner, is at the root of LOS. Our recent research has focused on understanding epigenetic alterations to imprinted genes that are associated with assisted reproductive technologies… CONTINUE READING
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