Developmental and cell cycle regulation of the Drosophila histone locus body.

@article{White2007DevelopmentalAC,
  title={Developmental and cell cycle regulation of the Drosophila histone locus body.},
  author={Anne E White and Michelle E. Leslie and Brian R Calvi and William Bill F Marzluff and Robert J. Duronio},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 7},
  pages={
          2491-502
        }
}
Cyclin E/Cdk2 is necessary for replication-dependent histone mRNA biosynthesis, but how it controls this process in early development is unknown. We show that in Drosophila embryos the MPM-2 monoclonal antibody, raised against a phosphoepitope from human mitotic cells, detects Cyclin E/Cdk2-dependent nuclear foci that colocalize with nascent histone transcripts. These foci are coincident with the histone locus body (HLB), a Cajal body-like nuclear structure associated with the histone locus and… CONTINUE READING