Developmental and behavioral toxicity following acute postnatal exposure of rat pups to trimethyltin.

@article{Ruppert1983DevelopmentalAB,
  title={Developmental and behavioral toxicity following acute postnatal exposure of rat pups to trimethyltin.},
  author={Patricia H. Ruppert and Kirsti Dean and Lieselotte Reiter},
  journal={Neurobehavioral toxicology and teratology},
  year={1983},
  volume={5 4},
  pages={421-9}
}
The purpose of this study was to extend our investigations on the developmental neurotoxicity of trialkyltin compounds. On postnatal day 5 (PND 5), rat pups received a single intraperitoneal injection of either 0 (saline), 4, 5 or 6 mg/kg trimethyltin hydroxide (TMT) calculated as the base. The size of the milk bands was decreased in 6 mg/kg TMT pups 48-96 hr after dosing, while in 5 mg/kg TMT pups, milk bands were reduced 96 hr after dosing only. Dosages of 5 and 6 mg/kg TMT reduced growth and… CONTINUE READING