Developmental Vitamin D3 deficiency alters the adult rat brain.

  title={Developmental Vitamin D3 deficiency alters the adult rat brain.},
  author={François F{\'e}ron and Thomas H J Burne and Justin Brown and Eleanor Smith and J J Mcgrath and Alan Mackay-Sim and Darryl Walter Eyles},
  journal={Brain research bulletin},
  volume={65 2},
There is growing evidence that Vitamin D(3) (1,25-dihydroxyvitamin D(3)) is involved in brain development. We have recently shown that the brains of newborn rats from Vitamin D(3) deficient dams were larger than controls, had increased cell proliferation, larger lateral ventricles, and reduced cortical thickness. Brains from these animals also had reduced expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor. The aim of the current study was to examine if there… CONTINUE READING


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