Developmental Regulation of GTP-CH1 in the Porcine Lung and Its Relationship to Pulmonary Vascular Relaxation

@article{Nandi2006DevelopmentalRO,
  title={Developmental Regulation of GTP-CH1 in the Porcine Lung and Its Relationship to Pulmonary Vascular Relaxation},
  author={Manasi Nandi and James M. Leiper and Francesca I Arrigoni and Alison A Hislop and Patrick J. T. Vallance and Sheila. G. Haworth},
  journal={Pediatric Research},
  year={2006},
  volume={59},
  pages={767-772}
}
Nitric oxide (NO) plays an important role in lowering pulmonary vascular resistance after birth. However, in persistent pulmonary hypertension of the newborn (PPHN) NO-mediated dilation is dysfunctional. GTP-cyclohydrolase 1 (GTP-CH1) is the rate-limiting enzyme for the biosynthesis of 6R-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4) an essential cofactor for nitric oxide synthase (NOS) activity. Suboptimal levels of BH4 may result in NOS uncoupling and the subsequent generation of harmful… CONTINUE READING