Developmental Regulation and Spatiotemporal Redistribution of the Sumoylation Machinery in the Rat Central Nervous System

@inproceedings{Loriol2012DevelopmentalRA,
  title={Developmental Regulation and Spatiotemporal Redistribution of the Sumoylation Machinery in the Rat Central Nervous System},
  author={C{\'e}line Loriol and Joséphine Parisot and Gw{\'e}nola Poupon and Carole Gwizdek and St{\'e}phane Martin},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Small Ubiquitin-like MOdifier protein (SUMO) is a key regulator of nuclear functions but little is known regarding the role of the post-translational modification sumoylation outside of the nucleus, particularly in the Central Nervous System (CNS). METHODOLOGY/PRINCIPAL FINDINGS Here, we report that the expression levels of SUMO-modified substrates as well as the components of the sumoylation machinery are temporally and spatially regulated in the developing rat brain… CONTINUE READING

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