Developmental Potential for Endomorphin Opioidmimetic Drugs

@article{Okada2012DevelopmentalPF,
  title={Developmental Potential for Endomorphin Opioidmimetic Drugs},
  author={Y. Okada and Y. Tsuda and S. Salvadori and L. Lazarus},
  journal={International Journal of Medicinal Chemistry},
  year={2012},
  volume={2012}
}
Morphine, which is agonist for μ-opioid receptors, has been used as an anti-pain drug for millennia. The opiate antagonists, naloxone and naltrexone, derived from morphine, were employed for drug addiction and alcohol abuse. However, these exogenous agonists and antagonists exhibit numerous and unacceptable side effects. Of the endogenous opioid peptides, endomorphin(EM)-1 and endomorphin(EM)-2 with their high μ-receptor affinity and exceptionally high selectivity relative to δ- and κ-receptors… Expand
3 Citations
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