Developmental Functional Adaptation to High Altitude: Review

@article{Frisancho2013DevelopmentalFA,
  title={Developmental Functional Adaptation to High Altitude: Review},
  author={A. R. Frisancho},
  journal={American Journal of Human Biology},
  year={2013},
  volume={25}
}
Various approaches have been used to understand the origins of the functional traits that characterize the Andean high‐altitude native. Based on the conceptual framework of developmental functional adaptation which postulates that environmental influences during the period of growth and development have long lasting effects that may be expressed during adulthood, we initiated a series of studies addressed at determining the pattern of physical growth and the contribution of growth and… Expand
Case Study: Developmental Physiology at High Altitude
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Developmental hypoxia determines the ability of adult mammals to withstand life at high altitude, and the available data indicate that this might be an important driving force in short-term acclimatization and long-term adaptation to high altitude. Expand
Genetic and phenotypic differentiation of an Andean intermediate altitude population
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Overall, this study shows that some phenotypic and genetic differentiation occurs at intermediate altitude in response to moderate lifelong selection pressures. Expand
Morphological signatures of high-altitude adaptations in the Andean archaeological record: Distinguishing developmental plasticity and natural selection
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Comparisons of patterns of intrinsic variation and sexual dimorphism in body size, limb lengths, and rib morphology in highland and lowland groups to test whether developmental plasticity or natural selection underlies these morphological differences. Expand
Human Adaptation to Life at High Altitude
TLDR
Data related to birth weight, gestational age, preeclampsia, hemoglobin and chronic mountain sickness in populations at HA are reviewed and how gene evolution drives adaptation is reviewed. Expand
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TLDR
The adaptations acquired during growth and development at altitude are critical for promoting complete functional adaptation to hypoxic stress. Expand
Persistent structural adaptation in the lungs of guinea pigs raised at high altitude
TLDR
Prolonged HA residence demonstrated persistent augmentation of some but not all aspects of lung structure throughout prolonged HA residence, with partial reversibility following re-acclimatization to IA. Expand
Glucose homeostasis during short-term and prolonged exposure to high altitudes.
TLDR
The most current evidence about glucose homeostasis in residents living above 1500 m is presented and possible mechanisms that could explain the lower fasting glycemia and lower prevalence of obesity and diabetes in this population are discussed. Expand
Physical Growth, Biological Age, and Nutritional Transitions of Adolescents Living at Moderate Altitudes in Peru
TLDR
Adolescents living at a moderate altitude in Peru exhibited stunted linear growth and biological maturation and showed the presence of the double nutritional burden (stunted growth and excessive weight). Expand
Evidence for and Against Genetic Predispositions to Acute and Chronic Altitude Illnesses.
TLDR
In the past 5 years, the use of genomic techniques has helped bolster the claim that susceptibility to some altitude illnesses is likely the result of genetic variation. Expand
Evidence for and Against Genetic Predispositions to Acute and Chronic Altitude Illnesses.
TLDR
For each of the major altitude illnesses, the collection of more individual, familial, and biogeographical susceptibility data should improve the understanding of the extent to which genetic variation contributes to altitude illness susceptibility, and genomic and molecular investigations have the potential to elucidate the mechanisms that underpin altitude illnesses susceptibility. Expand
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