Developmental Expression of ROMK mRNA in Rabbit Cortical Collecting Duct

@article{Benchimol2000DevelopmentalEO,
  title={Developmental Expression of ROMK mRNA in Rabbit Cortical Collecting Duct},
  author={Corinne Benchimol and Beth J. Zavilowitz and Lisa M. Satlin},
  journal={Pediatric Research},
  year={2000},
  volume={47},
  pages={46-46}
}
The cortical collecting duct (CCD) is a major site of regulation of K+ homeostasis in the fully differentiated mammalian kidney. CCDs isolated from adult rabbits and microperfused in vitro secrete K+ into the tubular fluid at high rates. However, CCDs dissected from newborn animals show no significant net K+ secretion until the 3rd wk of life, at least in part because of a paucity of conducting apical secretory K+ (SK) channels. To determine whether the abundance of genes encoding the SK… CONTINUE READING
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