Developmental Down-Regulation of GAP-43 Expression and Timing of Target Contact in Rat Corticospinal Neurons

@article{KarimiAbdolrezaee2002DevelopmentalDO,
  title={Developmental Down-Regulation of GAP-43 Expression and Timing of Target Contact in Rat Corticospinal Neurons},
  author={Soheila Karimi-Abdolrezaee and Valerie M. K. Verge and David J. Schreyer},
  journal={Experimental Neurology},
  year={2002},
  volume={176},
  pages={390-401}
}
During early nervous system development axons grow toward the target tissue that they will innervate. As axons invade target tissue, growth slows and ceases. Neurons express high levels of the growth-associated protein GAP-43 during developmental axon growth, declining with maturation. It has been suggested that target contact provides a signal which down-regulates GAP-43 expression. To study this issue in more detail, we used in situ hybridization to quantify relative changes in GAP-43 mRNA in… CONTINUE READING
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