Developmental Constraints on Vertebrate Genome Evolution

@article{Roux2008DevelopmentalCO,
  title={Developmental Constraints on Vertebrate Genome Evolution},
  author={Julien Roux and Marc Robinson-Rechavi},
  journal={PLoS Genetics},
  year={2008},
  volume={4}
}
Constraints in embryonic development are thought to bias the direction of evolution by making some changes less likely, and others more likely, depending on their consequences on ontogeny. Here, we characterize the constraints acting on genome evolution in vertebrates. We used gene expression data from two vertebrates: zebrafish, using a microarray experiment spanning 14 stages of development, and mouse, using EST counts for 26 stages of development. We show that, in both species, genes… 

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