Developmental Changes in the in Vitro Activated Regenerative Activity of Primitive Mammary Epithelial Cells

@inproceedings{Makarem2013DevelopmentalCI,
  title={Developmental Changes in the in Vitro Activated Regenerative Activity of Primitive Mammary Epithelial Cells},
  author={Maisam Makarem and Nagarajan Kannan and Long Vo Nguyen and David J H F Knapp and Sneha Balani and Michael D. Prater and John Stingl and Afshin Raouf and Oksana Nemirovsky and Peter D. Eirew and Connie J. Eaves},
  booktitle={PLoS biology},
  year={2013}
}
Many normal adult tissues contain rare stem cells with extensive self-maintaining regenerative potential. During development, the stem cells of the hematopoietic and neural systems undergo intrinsically specified changes in their self-renewal potential. In the mouse, mammary stem cells with transplantable regenerative activity are first detectable a few days before birth. They share some phenotypic properties with their adult counterparts but are enriched in a subpopulation that displays a… CONTINUE READING
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