Developmental Changes in the in Vitro Activated Regenerative Activity of Primitive Mammary Epithelial Cells

  title={Developmental Changes in the in Vitro Activated Regenerative Activity of Primitive Mammary Epithelial Cells},
  author={Maisam Makarem and N. Kannan and L. Nguyen and D. Knapp and Sneha Balani and Michael D. Prater and J. Stingl and Afshin Raouf and Oksana Nemirovsky and P. Eirew and C. Eaves},
  journal={PLoS Biology},
  • Maisam Makarem, N. Kannan, +8 authors C. Eaves
  • Published 2013
  • Biology, Medicine
  • PLoS Biology
  • Mouse fetal mammary cells display greater regenerative activity than do adult mammary cells when stimulated to proliferate in a new system that supports the production of transplantable mammary stem cells ex vivo. 

    Figures, Tables, and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Mammary stem cells and the differentiation hierarchy: current status and perspectives.
    • 367
    • PDF
    Mammary gland development: cell fate specification, stem cells and the microenvironment
    • 202
    • PDF
    Quantification of regenerative potential in primary human mammary epithelial cells
    • 67
    • PDF
    Stem Cells and the Developing Mammary Gland
    • 37
    • PDF
    CRIPTO/GRP78 Signaling Maintains Fetal and Adult Mammary Stem Cells Ex Vivo
    • 49
    • Highly Influenced
    • PDF


    Publications referenced by this paper.
    Purification and unique properties of mammary epithelial stem cells
    • 1,444
    Generation of a functional mammary gland from a single stem cell
    • 1,839
    • PDF
    Distinct stem cells contribute to mammary gland development and maintenance
    • 642
    • PDF
    Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis.
    • 532
    • PDF
    Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture.
    • 360
    • Highly Influential
    • PDF
    An entire functional mammary gland may comprise the progeny from a single cell.
    • 547
    • PDF
    A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer.
    • 170
    • Highly Influential
    • PDF