Developmental Changes in Rat Brain 5′-Deiodinase and Thyroid Hormones during the Fetal Period: The Effects of Fetal Hypothyroidism and Maternal Thyroid Hormones

@article{Oa1988DevelopmentalCI,
  title={Developmental Changes in Rat Brain 5′-Deiodinase and Thyroid Hormones during the Fetal Period: The Effects of Fetal Hypothyroidism and Maternal Thyroid Hormones},
  author={Carmen Ruiz De O{\~n}a and Mar{\'i}a Jes{\'u}s Obreg{\'o}n and Francisco Escobar Del Rey and Gabriella Morreale De Escobar},
  journal={Pediatric Research},
  year={1988},
  volume={24},
  pages={588-594}
}
ABSTRACT: We have studied the ontogenesis of 5′-deiodinase (5′D) activity in rat brain during fetal life, its capacity to respond to maternal or fetal hypothyroidism, and its regulation by maternal thyroid hormones. Type II 5′D (5′ D-II) activity increases 4-fold during the period studied (17 to 22 days of gestation), mainly between days 19 and 21. Fetal brain T4 concentrations increase in parallel with fetal plasma T4, whereas fetal brain T3 concentrations increase 18 times (days 17–21), six… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 44 references

Thyroid hormone effects on growth and development

J Legrand
1986

Thyroid hormone effects on growth and development. IN: Hennemann G (ed) Thyroid Hormone Metabolism

J Legrand
1986

Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues , before and after onset of fetal thyroid function

G MorrealedeEscobar, R Pastor, MJ Obregon, F EscobardelRey
Endocrinology • 1985

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