Development trends for therapeutic antibody fragments

  title={Development trends for therapeutic antibody fragments},
  author={Aaron L A Nelson and Janice M. Reichert},
  journal={Nature Biotechnology},
Monoclonal antibodies (mAbs) are an increasingly important class of therapeutic agents. Twenty-two mAbs have been approved for therapeutic use in the United States, and over 200 mAb candidates are in the clinical pipeline1. The approved products accounted for ~$20 billion of healthcare spending in 2006 (ref. 2), and the market is growing at ~14% per year3. Eight mAbs had sales >$1 billion in 2007, with Rituxan (rituximab; Genentech, S. San Francisco, CA, USA) being the bestseller, with sales of… CONTINUE READING
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