Development of valuable yeast strains using a novel mutagenesis technique for the effective production of therapeutic glycoproteins.

@article{Abe2009DevelopmentOV,
  title={Development of valuable yeast strains using a novel mutagenesis technique for the effective production of therapeutic glycoproteins.},
  author={Hiroko Abe and Yuki Takaoka and Yasunori Chiba and Natsuko Sato and Satoru Ohgiya and Akiko Itadani and Mitsuomi Hirashima and Chikashi Shimoda and Y. Jigami and Ken-ichi Nakayama},
  journal={Glycobiology},
  year={2009},
  volume={19 4},
  pages={428-36}
}
Yeast cells producing mammalian-type N-linked oligosaccharide show severe growth defects and the decreased protein productivity because of the disruption of yeast-specific glycosyltransferases. This decreased protein productivity in engineered yeast strains is an obstacle to the development of efficient glycoprotein production in yeast. For economic and effective synthesis of such therapeutic glycoproteins in yeast, the development of appropriate strains is highly desirable. We applied a novel… CONTINUE READING

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