Development of vaccines for prevention of botulism.

@article{Byrne2000DevelopmentOV,
  title={Development of vaccines for prevention of botulism.},
  author={Marann Byrne and Leonard A. Smith},
  journal={Biochimie},
  year={2000},
  volume={82 9-10},
  pages={
          955-66
        }
}
Botulism is a potentially lethal disease caused by one of seven homologous neurotoxic proteins usually produced by the bacterium, Clostridium botulinum. This neuromuscular disorder occurs through an exquisite series of molecular events, ultimately ending with the arrest of acetylcholine release and hence, flaccid paralysis. The development of vaccines that protect against botulism dates back to the 1940s. Currently, a pentavalent vaccine that protects against BoNT serotypes A-E and a separate… CONTINUE READING

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