Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish.

@article{Riley2000DevelopmentOU,
  title={Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish.},
  author={Bruce B. Riley and Stephen J Moorman},
  journal={Journal of neurobiology},
  year={2000},
  volume={43 4},
  pages={329-37}
}
We have been studying the consequences of embryonic vestibular dysfunction caused by the monolith (mnl) mutation in zebrafish. mnl is a dominant mutation that specifically inhibits formation of utricular otoliths. However, briefly immobilizing mnl/mnl embryos in agarose with the otic vesicle orientated at certain angles selectively induces or prevents formation of utricular and/or saccular otoliths. With this noninvasive technique, we generated six phenotypic classes of mnl/mnl mutants… CONTINUE READING

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