Development of two-kidney Goldblatt hypertension in rats under dietary sodium restriction.

@article{MunozRamirez1980DevelopmentOT,
  title={Development of two-kidney Goldblatt hypertension in rats under dietary sodium restriction.},
  author={H. Munoz-Ramirez and R. Chatelain and F. M. Bumpus and P. Khairallah},
  journal={The American journal of physiology},
  year={1980},
  volume={238 6},
  pages={
          H889-94
        }
}
In Sprague-Dawley rats with unilateral renal artery stenosis and an intact contralateral kidney, administration of a low-sodium diet did not prevent the development of hypertension. Despite an elevated blood pressure, hyponatremia, marked activation of the renin-angiotensin system, and increased hematocrit values, only 10% of the rats showed lesions of malignant hypertension. Systolic blood pressures of one- and two-kidney sham-operated rats fed a low-sodium diet were significantly higher than… Expand
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