Development of two-kidney Goldblatt hypertension in rats under dietary sodium restriction.

  title={Development of two-kidney Goldblatt hypertension in rats under dietary sodium restriction.},
  author={H. Munoz-Ramirez and R. Chatelain and F. M. Bumpus and P. Khairallah},
  journal={The American journal of physiology},
  volume={238 6},
In Sprague-Dawley rats with unilateral renal artery stenosis and an intact contralateral kidney, administration of a low-sodium diet did not prevent the development of hypertension. Despite an elevated blood pressure, hyponatremia, marked activation of the renin-angiotensin system, and increased hematocrit values, only 10% of the rats showed lesions of malignant hypertension. Systolic blood pressures of one- and two-kidney sham-operated rats fed a low-sodium diet were significantly higher than… Expand
Role of sodium in hypertensive cardiac hypertrophy.
Activation of the renin-angiotensin system by a low-salt diet does not augment intratubular angiotensinogen and angiotensin II in rats.
Effect of sodium deprivation on cardiac hypertrophy in spontaneously hypertensive rats: influence of aging.
  • S. Sen, D. Young
  • Chemistry, Medicine
  • Journal of molecular and cellular cardiology
  • 1991
The role of the renin-angiotensin system in the regulation of erythropoiesis.
Glomerular function reserve and sodium sensitivity
  • G. Kimura
  • Medicine
  • Clinical and Experimental Nephrology
  • 2005