Development of trastuzumab-resistant human gastric carcinoma cell lines and mechanisms of drug resistance

@inproceedings{Zuo2015DevelopmentOT,
  title={Development of trastuzumab-resistant human gastric carcinoma cell lines and mechanisms of drug resistance},
  author={Qiang Zuo and Jing Liu and Jingwen Zhang and Mengwan Wu and Lihong Guo and Wangjun Liao},
  booktitle={Scientific reports},
  year={2015}
}
Trastuzumab has been successfully employed for the treatment of Her-2-positive gastric cancer. However, there are problems with both primary and secondary resistance to trastuzumab. In this study, we employed the human gastric carcinoma cell line NCI-N87 with high Her-2 expression to create trastuzumab-resistant NCI-N87/TR cells by stepwise exposure to increasing doses of trastuzumab. Western blotting and Real-time PCR were conducted to detect protein and gene levels. Compared with NCI-N87… CONTINUE READING
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