Development of transgenic rats producing human β-amyloid precursor protein as a model for Alzheimer's disease: Transgene and endogenous APP genes are regulated tissue-specifically

@article{Agca2007DevelopmentOT,
  title={Development of transgenic rats producing human β-amyloid precursor protein as a model for Alzheimer's disease: Transgene and endogenous APP genes are regulated tissue-specifically},
  author={Cansu Agca and Jason J Fritz and L Chandler Walker and Allan I. Levey and Anthony W. S. Chan and James J Lah and Yuksel Agca},
  journal={BMC Neuroscience},
  year={2007},
  volume={9},
  pages={28 - 28}
}
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that affects a large and growing number of elderly individuals. In addition to idiopathic disease, AD is also associated with autosomal dominant inheritance, which causes a familial form of AD (FAD). Some instances of FAD have been linked to mutations in the β-amyloid protein precursor (APP). Although there are numerous mouse AD models available, few rat AD models, which have several advantages over mice, have been generated… CONTINUE READING
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