Development of transgenic livestock with reduced myostatin expression using RNA interference.

  title={Development of transgenic livestock with reduced myostatin expression using RNA interference.},
  author={Kimberly J Tessanne and Todd K. Stroud and Charles R. Long and Gregory J. Hannon and Sanaz Sadeghieh and Earl Hwang and S. H. Chen and Irina A. Polejaeva and Mark E. Westhusin},
  journal={Reproduction, Fertility and Development},
RNA interference (RNAi) is a means of regulating gene expression by targeting mRNA in a sequence-specific manner for degradation or translational inhibition. Short hairpin RNAs (shRNAs) and siRNAs have been extensively employed for manipulating gene expression in a wide range of species. However, the great majority of this work has involved in vitro studies with cells grown in culture. Our goal for this project is to produce transgenic livestock in which myostatin, a negative regulator of… Expand


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