Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma.

@article{Ren2010DevelopmentOT,
  title={Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma.},
  author={Wei-hua Ren and Jiang Chang and Cheng-hu Yan and Xiao-min Qian and Li-xia Long and Bin He and Xu-bo Yuan and Chunsheng Kang and Didier Betbeder and Jing Sheng and Peiyu Pu},
  journal={Journal of materials science. Materials in medicine},
  year={2010},
  volume={21 9},
  pages={2673-81}
}
The aim of present study is to conceive a biodegradable poly(ethylene glycol)-polylactide (PEG-PLA) copolymer nanoparticle which can be surface biofunctionalized with ligands via biotin-avidin interactions and used as a potential drug delivery carrier targeting to brain glioma in vivo. For this aim, a new method was employed to synthesize biotinylated PEG-PLA copolymers, i.e., esterification of PEG with biotinyl chloride followed by copolymerization of hetero-biotinylated PEG with lactide. PEG… CONTINUE READING
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